Phosphatidylethanolamine binding protein 1

PDB rendering based on 1a44.

Available structures
PDB	1BD9, 1BEH, 2QYQ

Identifiers

Symbols

PEBP1; HCNP; PBP; PEBP; RKIP

External IDs

OMIM: 604591 MGI: 1344408 HomoloGene: 37637 GeneCards: PEBP1 Gene

Gene Ontology
Molecular function	• nucleotide binding • serine-type endopeptidase inhibitor activity • receptor binding • protein binding • ATP binding • lipid binding • phosphatidylethanolamine binding • peptidase inhibitor activity • mitogen-activated protein kinase binding
Cellular component	• extracellular space • soluble fraction • cytoplasm • mitochondrion • mitochondrial outer membrane • rough endoplasmic reticulum • Golgi apparatus • synaptic vesicle • cell surface • synaptosome • neuronal cell body • axon terminus • apical part of cell
Biological process	• regulation of neurotransmitter levels • negative regulation of protein phosphorylation • regulation of the force of heart contraction • response to oxidative stress • spermatid development • brain development • aging • response to heat • response to wounding • response to toxin • response to organic nitrogen • response to organic cyclic compound • response to activity • response to drug • eating behavior • negative regulation of MAPKKK cascade • positive regulation of cAMP-mediated signaling • response to ethanol • positive regulation of mitosis • response to corticosterone stimulus • response to cAMP • response to calcium ion • response to electrical stimulus • positive regulation of acetylcholine metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
118.57 – 118.58 Mb

Chr 5:
117.73 – 117.74 Mb

PubMed search

[1]

[2]

Phosphatidylethanolamine-binding protein 1 is a protein that in humans is encoded by the PEBP1 gene.^[1]^[2]

Interactions

Phosphatidylethanolamine binding protein 1 has been shown to interact with MAP2K1,^[3] C-Raf^[3] and MAPK1.^[3]

References

^ Park S, Yeung ML, Beach S, Shields JM, Yeung KC (May 2005). "RKIP downregulates B-Raf kinase activity in melanoma cancer cells". Oncogene 24 (21): 3535–40. doi:10.1038/sj.onc.1208435. PMID 15782137.
^ "Entrez Gene: PEBP1 phosphatidylethanolamine binding protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5037.
^ ^a ^b ^c Yeung, K; Janosch P, McFerran B, Rose D W, Mischak H, Sedivy J M, Kolch W (May. 2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein". Mol. Cell. Biol. (UNITED STATES) 20 (9): 3079–85. doi:10.1128/MCB.20.9.3079-3085.2000. ISSN 0270-7306. PMC 85596. PMID 10757792. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85596.

Schoentgen F, Jollès P (1995). "From structure to function: possible biological roles of a new widespread protein family binding hydrophobic ligands and displaying a nucleotide binding site.". FEBS Lett. 369 (1): 22–6. doi:10.1016/0014-5793(95)00376-K. PMID 7641877.
Ojika K, Mitake S, Tohdoh N, et al. (2000). "Hippocampal cholinergic neurostimulating peptides (HCNP).". Prog. Neurobiol. 60 (1): 37–83. doi:10.1016/S0301-0082(99)00021-0. PMID 10622376.
Odabaei G, Chatterjee D, Jazirehi AR, et al. (2004). "Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis.". Adv. Cancer Res. 91: 169–200. doi:10.1016/S0065-230X(04)91005-6. PMID 15327891.
Hochstrasser DF, Frutiger S, Paquet N, et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison.". Electrophoresis 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Tohdoh N, Tojo S, Agui H, Ojika K (1995). "Sequence homology of rat and human HCNP precursor proteins, bovine phosphatidylethanolamine-binding protein and rat 23-kDa protein associated with the opioid-binding protein.". Brain Res. Mol. Brain Res. 30 (2): 381–4. doi:10.1016/0169-328X(95)00029-R. PMID 7637590.
Seddiqi N, Bollengier F, Alliel PM, et al. (1995). "Amino acid sequence of the Homo sapiens brain 21-23-kDa protein (neuropolypeptide h3), comparison with its counterparts from Rattus norvegicus and Bos taurus species, and expression of its mRNA in different tissues.". J. Mol. Evol. 39 (6): 655–60. doi:10.1007/BF00160411. PMID 7807553.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hori N, Chae KS, Murakawa K, et al. (1994). "A human cDNA sequence homologue of bovine phosphatidylethanolamine-binding protein.". Gene 140 (2): 293–4. doi:10.1016/0378-1119(94)90562-2. PMID 8144042.
Moore C, Perry AC, Love S, Hall L (1996). "Sequence analysis and immunolocalisation of phosphatidylethanolamine binding protein (PBP) in human brain tissue.". Brain Res. Mol. Brain Res. 37 (1-2): 74–8. doi:10.1016/0169-328X(95)00285-Z. PMID 8738137.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Banfield MJ, Barker JJ, Perry AC, Brady RL (1998). "Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction.". Structure 6 (10): 1245–54. doi:10.1016/S0969-2126(98)00125-7. PMID 9782050.
Yeung K, Seitz T, Li S, et al. (1999). "Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP.". Nature 401 (6749): 173–7. doi:10.1038/43686. PMID 10490027.
Yeung K, Janosch P, McFerran B, et al. (2000). "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein.". Mol. Cell. Biol. 20 (9): 3079–85. doi:10.1128/MCB.20.9.3079-3085.2000. PMC 85596. PMID 10757792. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85596.
Hengst U, Albrecht H, Hess D, Monard D (2001). "The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors.". J. Biol. Chem. 276 (1): 535–40. doi:10.1074/jbc.M002524200. PMID 11034991.
Yeung KC, Rose DW, Dhillon AS, et al. (2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation.". Mol. Cell. Biol. 21 (21): 7207–17. doi:10.1128/MCB.21.21.7207-7217.2001. PMC 99896. PMID 11585904. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99896.
Maki M, Matsukawa N, Yuasa H, et al. (2002). "Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease.". J. Neuropathol. Exp. Neurol. 61 (2): 176–85. PMID 11853019.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=187542.

PDB gallery

1a44: PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN FROM CALF BRAIN

1b7a: STRUCTURE OF THE PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN FROM BOVINE BRAIN

1bd9: HUMAN PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN

1beh: HUMAN PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN IN COMPLEX WITH CACODYLATE

Phosphatidylethanolamine binding protein 1

Interactions

References

Further reading